Ayman O S El-Kadi Selected Research

beta-Naphthoflavone

4/2010	2,3,7,8-Tetrachlorodibenzo-p-dioxin and beta-naphthoflavone induce cellular hypertrophy in H9c2 cells by an aryl hydrocarbon receptor-dependant mechanism.
11/2004	Benzo[a]pyrene, 3-methylcholanthrene and beta-naphthoflavone induce oxidative stress in hepatoma hepa 1c1c7 Cells by an AHR-dependent pathway.
10/2004	Modulation of aryl hydrocarbon receptor-regulated gene expression by arsenite, cadmium, and chromium.
9/2004	Differential effects of mercury, lead and copper on the constitutive and inducible expression of aryl hydrocarbon receptor (AHR)-regulated genes in cultured hepatoma Hepa 1c1c7 cells.

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Ayman O S El-Kadi Research Topics

Disease

31	Hepatocellular Carcinoma (Hepatoma) 03/2016 - 08/2002
25	Cardiomegaly (Heart Hypertrophy) 01/2022 - 02/2008
23	Neoplasms (Cancer) 09/2021 - 04/2004
17	Cardiovascular Diseases (Cardiovascular Disease) 03/2022 - 01/2006
13	Cardiotoxicity 01/2019 - 12/2007
12	Hypertrophy 01/2022 - 04/2010
10	Inflammation (Inflammations) 01/2020 - 03/2005
8	Heart Failure 01/2022 - 02/2008
6	Body Weight (Weight, Body) 02/2014 - 01/2007
4	Obesity 01/2022 - 01/2017
3	Diabetic Cardiomyopathies 01/2022 - 07/2013
3	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2022 - 01/2018
3	Breast Neoplasms (Breast Cancer) 08/2020 - 04/2015
3	Hyperlipidemias (Hyperlipidemia) 03/2020 - 09/2008
3	Liver Diseases (Liver Disease) 01/2020 - 08/2002
3	Hypertension (High Blood Pressure) 01/2016 - 03/2010
3	Carcinogenesis 04/2015 - 02/2007
3	Melanoma (Melanoma, Malignant) 06/2011 - 02/2010
2	Insulin Resistance 01/2022 - 04/2014
2	COVID-19 01/2021 - 11/2020
2	Myocardial Infarction 08/2020 - 05/2015
2	Ischemia 01/2017 - 07/2013
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2013 - 02/2009
2	Experimental Melanoma 06/2011 - 02/2010
1	Cytokine Release Syndrome 11/2020

Drug/Important Bio-Agent (IBA)

34	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2022 - 04/2004
29	EnzymesIBA 01/2022 - 04/2004
23	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 09/2021 - 09/2004
19	Arachidonic Acid (Vitamin F)IBA 01/2022 - 11/2008
13	Pharmaceutical PreparationsIBA 01/2021 - 04/2004
12	CytochromesIBA 01/2022 - 10/2004
11	Hydroxyeicosatetraenoic Acids (HETE)IBA 01/2022 - 10/2015
11	Proteins (Proteins, Gene)FDA Link 01/2020 - 03/2005
11	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 03/2016 - 09/2004
10	AcidsIBA 08/2020 - 02/2014
10	Epoxide HydrolasesIBA 01/2019 - 12/2009
10	Messenger RNA (mRNA)IBA 01/2018 - 03/2005
10	Polychlorinated Dibenzodioxins (TCDD)IBA 11/2013 - 09/2004
10	Oxidoreductases (Dehydrogenase)IBA 11/2012 - 04/2004
9	NAD (NADH)IBA 11/2012 - 09/2004
9	quinone (benzoquinone)IBA 11/2012 - 09/2004
8	Angiotensin IIIBA 01/2022 - 07/2013
7	20-hydroxy-5,8,11,14-eicosatetraenoic acidIBA 01/2022 - 12/2009
7	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2018 - 10/2008
6	Isoproterenol (Isoprenaline)FDA LinkGeneric 05/2017 - 11/2008
6	Benzo(a)pyreneIBA 12/2011 - 09/2004
5	Atrial Natriuretic Factor (ANF)IBA 08/2020 - 12/2009
5	LigandsIBA 04/2015 - 09/2004
5	MercuryIBA 04/2014 - 09/2004
5	MethylcholanthreneIBA 12/2011 - 09/2004
5	Glutathione Transferase (Glutathione S-Transferase)IBA 02/2007 - 09/2004
4	Myosin Heavy Chains (Myosin Heavy Chain)IBA 08/2020 - 12/2015
4	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2020 - 12/2009
4	VanadiumIBA 11/2013 - 05/2009
4	beta-NaphthoflavoneIBA 04/2010 - 09/2004
4	Heavy MetalsIBA 02/2008 - 09/2004
3	Fluconazole (Zonal)FDA LinkGeneric 01/2022 - 05/2007
3	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 04/2014
3	19-hydroxy-5,8,11,14-eicosatetraenoic acidIBA 09/2021 - 12/2015
3	ResveratrolIBA 08/2020 - 04/2010
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2018 - 05/2003
3	Ketoconazole (Nizoral)FDA LinkGeneric 03/2016 - 05/2007
3	Mixed Function Oxygenases (Monooxygenases)IBA 11/2012 - 05/2010
3	DioxinsIBA 02/2012 - 05/2010
3	Small Interfering RNA (siRNA)IBA 06/2011 - 02/2010
3	stearic acid (magnesium stearate)FDA LinkGeneric 06/2011 - 02/2010
3	PolyethyleneimineIBA 06/2011 - 02/2010
2	EicosanoidsIBA 01/2022 - 01/2020
2	LipidsIBA 01/2022 - 02/2010
2	Insulin (Novolin)FDA Link 01/2022 - 04/2014
2	ElementsIBA 11/2020 - 02/2016
2	AntioxidantsIBA 01/2018 - 04/2015
2	Interleukin-6 (Interleukin 6)IBA 01/2018 - 02/2010
2	Mitogen-Activated Protein KinasesIBA 05/2017 - 03/2016
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 09/2006
2	SaltsIBA 01/2016 - 07/2013
2	Desoxycorticosterone Acetate (DOCA)FDA Link 01/2016 - 07/2013
2	Acetates (Acetic Acid Esters)FDA Link 01/2016 - 07/2013
2	Desoxycorticosterone (Deoxycorticosterone)IBA 01/2016 - 07/2013
2	ArsenicIBA 10/2015 - 12/2012
2	CarcinogensIBA 04/2015 - 12/2007
2	XenobioticsIBA 11/2014 - 05/2009
2	thiouredopyrenetrisulfonateIBA 04/2013 - 03/2011
2	CytokinesIBA 01/2013 - 02/2008
2	Antineoplastic Agents (Antineoplastics)IBA 11/2012 - 04/2004
2	HET0016IBA 11/2012 - 12/2009
2	QuinonesIBA 11/2011 - 08/2008
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 10/2010 - 02/2010
2	ammonium metavanadateIBA 10/2010 - 09/2010
2	LipopolysaccharidesIBA 05/2010 - 03/2005
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2010 - 10/2008
2	CopperIBA 02/2008 - 09/2004
2	AzolesIBA 12/2007 - 05/2007
2	Itraconazole (Sporanox)FDA LinkGeneric 12/2007 - 05/2007
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2007 - 03/2005
2	2-tert-butylhydroquinone (tert-butylhydroquinone)IBA 01/2007 - 03/2005
1	Matrix Metalloproteinases (MMPs)IBA 03/2022
1	Nonesterified Fatty Acids (NEFA)IBA 01/2022
1	12-Hydroxy-5,8,10,14-eicosatetraenoic AcidIBA 01/2022

Therapy/Procedure

1	Therapeutics 08/2020